This review is a survey of various approaches to targeting cytotoxic anticancer drugs to
tumors primarily through biomolecules expressed by cancer cells or associated vasculature …

Prodrug and drug delivery systems are two effective strategies for improving the selectivity of
chemotherapeutics. Molecularly imprinted polymers (MIPs) have emerged as promising …

High microvessel density, an indirect measure of angiogenesis, has been shown to correlate
with increased tumour size, lymph node involvement and poor prognosis in non-small-cell …

The reversible phosphorolysis of purine and pyrimidine nucleosides is an important
biochemical reaction in the salvage pathway, which provides an alternative to the de novo …

Thymidine phosphorylase (TP), also known as “platelet‐derived endothelial cell growth
factor”(PD‐ECGF), is an enzyme, which is upregulated in a wide variety of solid tumors …

Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated
by a complex network of factors produced by both stromal cells and neoplastic cells within …

The intracellular metabolism and cytostatic activity of the anticancer drug gemcitabine (2′,
2′-difluoro-2′-deoxycytidine; dFdC) was severely compromised in Mycoplasma hyorhinis …

Abstract Thymidine phosphorylase (TP)(EC 2.4. 2.4), also known as platelet-derived
endothelial cell growth factor, is a potent angiogenic factor. The expression of TP correlates …

In recent years the idea of using gene therapy as a modality in the treatment of diseases
other than genetically inherited, monogenic disorders has taken root. This is particularly …

Angiogenesis is the term used to describe the formation of new blood vessels from the
existing vasculature. In order to attract new vessels, a tissue must release an endothelial-cell …