Bioluminescence (BL) is a spectacular phenomenon involving light emission by live
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …

Although fluorescent reporters and biosensors have become indispensable tools in
biological and biomedical fields, fluorescence measurements require external excitation …

Red-shifted bioluminescence reporters are desirable for biological imaging. We describe the
development of red-shifted luciferins based on synthetic coelenterazine analogs and …

We describe here an extensive structure‐bioluminescence relationship study of a chemical
library of analogues of coelenterazine, using nanoKAZ/NanoLuc, a mutated luciferase …

Bioluminescence-based techniques, such as bioluminescence imaging, BRET and dual-
luciferase reporter assay systems, have been widely used to examine a myriad of biological …

NanoLuc luciferase recently gained popularity due to its small size and superior
bioluminescence performance. For in vivo imaging applications, NanoLuc has been limited …

An original gram-scale synthesis of O-acetylated forms of coelenterazine, furimazine or
hydroxy-bearing analogues of luciferins is described. The comparison over two hours of …

The small engineered luciferase NanoLuc has rapidly become a powerful tool in the fields of
biochemistry, chemical biology, and cell biology due to its exceptional brightness and …

Bioluminescence (BL) imaging, which utilizes light emitted through the enzymatic reaction of
luciferase oxidizing its substrate luciferin, enables sensitive and noninvasive monitoring of …

Hepatitis E virus (HEV) is a quasi-enveloped virus with a single-stranded positive-sense
RNA genome belonging to the family Hepeviridae. Studies of the molecular aspects of HEV …