Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …

Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …

Atherosclerosis (AS) is a chronic vascular disease characterized by lipid accumulation and
the activation of the inflammatory response; it remains the leading nation-wide cause of …

The glycolytic phenotype of the Warburg effect is associated with acidification of the tumor
microenvironment. In this review, we describe how acidification of the tumor …

Background Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-
bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate …

Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell
types and are particularly abundant in endothelial cells and adipocytes. The lipid …

The endothelial surface is a highly flexible signaling hub which is able to sense the
hemodynamic forces of the streaming blood. The subsequent mechanosignaling is basically …

Atherosclerosis is a common and deadly cardiovascular disease with extremely high
prevalence. Areas of the vasculature exposed to oscillatory shear stress (OSS) or disturbed …

Abstract Purpose of Review Wall shear stress describes the mechanical influence of blood
flow on the arterial wall. In this review, we discuss the role of the wall shear stress in the …