Aims The hereditary spastic paraplegias (HSPs) are a heterogeneous group of inherited
neurodegenerative disorders. Although, several genotype–phenotype studies have carried …

Hereditary spastic paraplegias (HSP) are a large group of genetic diseases characterized by
progressive degeneration of the long tracts of the spinal cord, namely the corticospinal tracts …

Objective: To describe the clinical, genetic, and epidemiologic features of hereditary spastic
paraplegia (HSP) in Canada and to determine which clinical, radiologic, and genetic factors …

ARL6IP1 is implicated in hereditary spastic paraplegia (HSP), but the specific pathogenic
mechanism leading to neurodegeneration has not been elucidated. Here, we clarified the …

Hereditary spastic paraplegia (HSP) is a diverse group of Mendelian genetic disorders
affecting the upper motor neurons, specifically degeneration of their distal axons in the …

Hereditary spastic paraplegia (HSP) is a heterogeneous group of rare motor neuron
disorders characterized by progressive weakness and spasticity of the lower limbs. HSP …

Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

Abstract Spastic paraplegia type 11 (SPG11) is a common autosomal recessive form of
hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor …

Background The cerebellar ataxia, neuropathy, and vestibular areflexia syndrome was
initially described in the early 1990s as a late‐onset slowly progressive condition. Its …

Background and Objectives AP-4-associated hereditary spastic paraplegia (AP-4-HSP:
SPG47, SPG50, SPG51, SPG52) is an emerging cause of childhood-onset hereditary …