Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone
development. In endochondral ossification, Runx2 induces chondrocyte maturation …

Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate
the mineralization of the skeleton. These cells work in harmony with osteoclasts, which …

Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

The adult human skeleton is a multifunctional organ undergoing continuous remodeling.
Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone …

Mutations in WNT1 cause osteogenesis imperfecta (OI) and early-onset osteoporosis,
identifying it as a key Wnt ligand in human bone homeostasis. However, how and where …

Wnt/β-catenin signaling is critical for various cellular processes in multiple cell types,
including osteoblast (OB) differentiation and function. Exactly how Wnt/β-catenin signaling is …

Type 1 diabetes (T1D)–induced osteoporosis is characterized by a predominant
suppression of osteoblast number and activity, as well as increased bone marrow adiposity …