The Rickettsiales are a group of obligate intracellular vector-borne Gram-negative bacteria
that include many organisms of clinical and agricultural importance, including Anaplasma …

Filariae are parasitic roundworms, which can cause debilitating diseases such as lymphatic
filariasis and onchocerciasis. Lymphatic filariasis, also known as elephantiasis, and …

Eosinophils mediate protection against filarial nematodes. Our results demonstrate that
eosinophil extracellular traps (EETosis) are induced by microfilariae and infective L3 larvae …

There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the
neglected tropical diseases onchocerciasis and lymphatic filariasis. From an anti-infective …

Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together
affect∼ 157 million people and inflict severe disability. Both diseases are caused by …

Filariae are vector-borne parasitic nematodes that are endemic worldwide, in tropical and
subtropical regions. Important human filariae spp. include Onchocerca volvulus, Wuchereria …

Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-
migrating phase is dominated by innate IL-17A production. In this study, we confirm previous …

Polymorphonuclear neutrophils (PMNs) are indispensable in fighting infectious microbes by
adopting various antimicrobial strategies including phagocytosis and neutrophil extracellular …

Litomosoides sigmodontis is the only filarial nematode where the full life cycle, from larval
delivery to the skin through to circulating microfilaria, can be completed in …

Depletion of Wolbachia endosymbionts of human pathogenic filariae using 4–6 weeks of
doxycycline treatment can lead to permanent sterilization and adult filarial death. We …