Experimental design has a long tradition in statistics, engineering and life sciences, dating
back to the beginning of the last century when optimal designs for industrial and agricultural …

Today the basic principles of septic conditions are understood. Nevertheless, sepsis
research has reached a critical point. To integrate our knowledge towards a consistent …

Empirical time series often contain observational noise. We investigate the effect of this
noise on the estimated parameters of models fitted to the data. For data of physiological …

We propose a method for the estimation of parameters of nonlinear delayed feedback
systems from a time series. Being based on the multiple shooting approach it is fairly robust …

Many physical systems exhibiting nonlinear spatiotemporal dynamics can be modeled by
partial differential equations. Although information about the physical properties for many of …

During the past decades the components involved in cellular signal transduction from
membrane receptors to gene activation in the nucleus have been studied in detail. Based on …

Ca2+ transients elicited by action potentials were measured using MagFluo‐4, at 20–22° C,
in intact muscle fibres enzymatically dissociated from mice of different ages (7, 10, 15 and 42 …

The determination of a differential equation underlying a measured time series is a
frequently arising task in nonlinear time series analysis. In the validation of a proposed …

Huntington's disease (HD) is caused by an expanded CAG trinucleotide repeat within the
gene encoding the protein huntingtin. The resulting elongated glutamine (poly-Q) sequence …

Ca2+ channels play crucial roles in cellular signal transduction and are important targets of
pharmacological agents. They are also associated with auxiliary subunits exhibiting …