Background This study used a bidirectional 2-sample Mendelian randomization study to
investigate the potential causal links between mtDNA copy number and cardiometabolic …

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights
a potential causal role in dementia | eLife Skip to Content eLife logo eLife home page Menu …

Mitochondrial DNA plays a critical role in the pathophysiological process of inflammation.
However, the relationship between mitochondrial DNA copy number (mtDNA-CN) and …

Increasingly large cross-ancestry GWAS meta-analyses have discovered over 100
independent genetic risk loci harboring common single nucleotide variants associated with …

Mitochondrial DNA (mtDNA) is a maternally inherited, high-copy-number genome required
for oxidative phosphorylation. Heteroplasmy refers to the presence of a mixture of mtDNA …

Abnormalities in the mitochondria have been linked to psoriasis, a chronic immune-
mediated inflammatory skin disease. The mitochondrial DNA (mtDNA) is present in …

A growing number of studies indicate that mitochondrial dysfunction serves as a
pathological mechanism for periodontitis. Therefore, this two-sample Mendelian …

Abstract Background Mitochondrial function influences Parkinson's disease (PD) through the
accumulation of pathogenic alpha‐synuclein, oxidative stress, impaired autophagy, and …

Background and aims Mitochondrial dysfunction is associated with increased reactive
oxygen species (ROS) that are thought to drive disease risk, including stroke. We …

Background Low leukocyte mitochondrial DNA (mtDNA) abundance has been associated
with a higher risk of atherosclerotic cardiovascular disease, but through unclear …