How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution

EA Groisman, A Duprey, J Choi - Microbiology and Molecular …, 2021 - journals.asm.org
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …

Salmonella Virulence and Immune Escape

M Wang, IH Qazi, L Wang, G Zhou, H Han - Microorganisms, 2020 - mdpi.com
Salmonella genus represents the most common foodborne pathogens causing morbidity,
mortality, and burden of disease in all regions of the world. The introduction of antimicrobial …

Assembly and maintenance of lipids at the bacterial outer membrane

E Lundstedt, D Kahne, N Ruiz - Chemical reviews, 2020 - ACS Publications
The outer membrane of Gram-negative bacteria is essential for their survival in harsh
environments and provides intrinsic resistance to many antibiotics. This membrane is …

Outer membrane lipid secretion and the innate immune response to gram-negative bacteria

NP Giordano, MB Cian, ZD Dalebroux - Infection and immunity, 2020 - journals.asm.org
The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that
consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The …

Structure of the essential inner membrane lipopolysaccharide–PbgA complex

T Clairfeuille, KR Buchholz, Q Li, E Verschueren, P Liu… - Nature, 2020 - nature.com
Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it
is responsible for barrier function,. LPS can cause death as a result of septic shock, and its …

Regulatory mechanisms of lipopolysaccharide synthesis in Escherichia coli

S Shu, W Mi - Nature Communications, 2022 - nature.com
Lipopolysaccharide (LPS) is an essential glycolipid and forms a protective permeability
barrier for most Gram-negative bacteria. In E. coli, LPS levels are under feedback control …

YhdP, TamB, and YdbH are redundant but essential for growth and lipid homeostasis of the Gram-negative outer membrane

N Ruiz, RM Davis, S Kumar - MBio, 2021 - journals.asm.org
The bacterial cell envelope is the first line of defense and point of contact with the
environment and other organisms. Envelope biogenesis is therefore crucial for the survival …

Border control: regulating LPS biogenesis

RL Guest, ST Rutherford, TJ Silhavy - Trends in Microbiology, 2021 - cell.com
The outer membrane (OM) is a defining feature of Gram-negative bacteria that serves as a
permeability barrier and provides rigidity to the cell. Critical to OM function is establishing …

YejM modulates activity of the YciM/FtsH protease complex to prevent lethal accumulation of lipopolysaccharide

RL Guest, D Samé Guerra, M Wissler, J Grimm… - MBio, 2020 - journals.asm.org
Lipopolysaccharide (LPS) is an essential glycolipid present in the outer membrane (OM) of
many Gram-negative bacteria. Balanced biosynthesis of LPS is critical for cell viability; too …

An essential membrane protein modulates the proteolysis of LpxC to control lipopolysaccharide synthesis in Escherichia coli

EM Fivenson, TG Bernhardt - MBio, 2020 - journals.asm.org
Gram-negative bacteria are surrounded by a complex cell envelope that includes two
membranes. The outer membrane prevents many drugs from entering these cells and is thus …