Regulation of membrane protein structure and function by their lipid nano-environment
Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …
metabolism, signalling, transport and many other functions required for cellular life. The …
Structural and functional consequences of reversible lipid asymmetry in living membranes
Maintenance of lipid asymmetry across the two leaflets of the plasma membrane (PM)
bilayer is a ubiquitous feature of eukaryotic cells. Loss of this asymmetry has been widely …
bilayer is a ubiquitous feature of eukaryotic cells. Loss of this asymmetry has been widely …
Membrane phase separation drives responsive assembly of receptor signaling domains
Plasma membrane heterogeneity has been tied to a litany of cellular functions and is often
explained by analogy to membrane phase separation; however, models based on phase …
explained by analogy to membrane phase separation; however, models based on phase …
LiPyphilic: A Python toolkit for the analysis of lipid membrane simulations
Molecular dynamics simulations are now widely used to study emergent phenomena in lipid
membranes with complex compositions. Here, we present LiPyphilic—a fast, fully tested …
membranes with complex compositions. Here, we present LiPyphilic—a fast, fully tested …
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients
Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-
prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has …
prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has …
Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain
Biological membranes are partitioned into functional zones termed membrane
microdomains, which contain specific lipids and proteins,–. The composition and …
microdomains, which contain specific lipids and proteins,–. The composition and …
Experimentally determined leaflet–leaflet phase diagram of an asymmetric lipid bilayer
We have determined the partial leaflet–leaflet phase diagram of an asymmetric lipid bilayer
at ambient temperature using asymmetric giant unilamellar vesicles (aGUVs). Symmetric …
at ambient temperature using asymmetric giant unilamellar vesicles (aGUVs). Symmetric …
Refinement of Singer-Nicolson fluid-mosaic model by microscopy imaging: Lipid rafts and actin-induced membrane compartmentalization
KGN Suzuki, A Kusumi - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
This year celebrates the 50th anniversary of the Singer-Nicolson fluid mosaic model for
biological membranes. The next level of sophistication we have achieved for understanding …
biological membranes. The next level of sophistication we have achieved for understanding …
Phase‐Separated Lipid‐Based Nanoparticles: Selective Behavior at the Nano‐Bio Interface
P Papadopoulou, R van der Pol… - Advanced …, 2024 - Wiley Online Library
The membrane‐protein interface on lipid‐based nanoparticles influences their in vivo
behavior. Better understanding may evolve current drug delivery methods toward effective …
behavior. Better understanding may evolve current drug delivery methods toward effective …
The membrane phase transition gives rise to responsive plasma membrane structure and function
Several groups have recently reported evidence for the emergence of domains in cell
plasma membranes when membrane proteins are organized by ligand binding or assembly …
plasma membranes when membrane proteins are organized by ligand binding or assembly …