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The Hippo pathway: biology and pathophysiology
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …
YAP and TAZ: a nexus for Hippo signaling and beyond
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …
The Hippo signaling pathway in stem cell biology and cancer
The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and
Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue …
Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue …
[HTML][HTML] Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry
Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding
heterotrimeric Gαq family members, have been identified in∼ 83% and∼ 6% of uveal and …
heterotrimeric Gαq family members, have been identified in∼ 83% and∼ 6% of uveal and …
[HTML][HTML] Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2
Although Merlin/NF2 was discovered two decades ago as a tumor suppressor underlying
Neurofibromatosis type II, its precise molecular mechanism remains poorly understood …
Neurofibromatosis type II, its precise molecular mechanism remains poorly understood …
A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis
YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif)
are major downstream effectors of the Hippo pathway that influences tissue homeostasis …
are major downstream effectors of the Hippo pathway that influences tissue homeostasis …
The Hippo pathway in intestinal regeneration and disease
The Hippo pathway is a signalling cascade conserved from Drosophila melanogaster to
mammals. The mammalian core kinase components comprise MST1 and MST2, SAV1 …
mammals. The mammalian core kinase components comprise MST1 and MST2, SAV1 …
The Hippo-YAP signaling pathway and contact inhibition of growth
BM Gumbiner, NG Kim - Journal of cell science, 2014 - journals.biologists.com
The Hippo-YAP pathway mediates the control of cell proliferation by contact inhibition as
well as other attributes of the physical state of cells in tissues. Several mechanisms sense …
well as other attributes of the physical state of cells in tissues. Several mechanisms sense …
[HTML][HTML] Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein
Hippo signaling is a tumor-suppressor pathway involved in organ size control and
tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress …
tumorigenesis through the inhibition of YAP and TAZ. Here, we show that energy stress …