Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional factor, which plays an
important role in cellular reprogramming processes under hypoxic conditions, which …

In the light of the enthusiasm regarding the use of recombinant human erythropoietin (Epo)
and its analogues for treatment of the anaemias of chronic renal failure and malignancies it …

Purpose To evaluate the effect on survival and quality of life of maintaining hemoglobin (Hb)
in the range of 12 to 14 g/dL with epoetin alfa versus placebo in women with metastatic …

Erythropoietin (Epo) has long been known to be the principal hematopoietic growth factor
that regulates cellular proliferation and differentiation along the erythroid lineage. Recent …

Erythropoietin (Epo) is an essential hormone that binds and activates the Epo receptor
(EpoR) resident on the surface of erythroid progenitor cells, thereby promoting …

The hormone erythropoietin (EPO) is essential for the survival, proliferation and
differentiation of the erythrocytic progenitors. The EPO receptor (EPO-R) of erythrocytic cells …

The primary function of the glycoprotein hormone erythropoietin (Epo) is to promote red cell
production by inhibiting apoptosis of erythrocytic progenitors in hemopoietic tissues …

The von Hippel-Lindau tumor suppressor gene (VHL) is best known as an E3 ubiquitin
ligase that negatively regulates the hypoxia inducible factor (HIF). VHL mutations are the …

Erythropoietin (EPO) is a moonlighting protein since is ability to work as hormone, cytokine
and growth factor. Its cardinal function is to regulate erythropoiesis in the bone marrow …

Thrombocytopenia is a common side effect of chemotherapy, responsible for increased risk
of bleeding and delay of treatment schedules in cancer patients. It is currently unknown how …