Imaging of sugar‐based contrast agents using their hydroxyl proton exchange properties

L Knutsson, X Xu, PCM van Zijl… - NMR in …, 2023‏ - Wiley Online Library
The ability of CEST MRI to detect the presence of millimolar concentrations of non‐metallic
contrast agents has made it possible to study, non‐invasively, important biological …

Repurposing clinical agents for chemical exchange saturation transfer magnetic resonance imaging: current status and future perspectives

Z Chen, Z Han, G Liu - Pharmaceuticals, 2020‏ - mdpi.com
Molecular imaging is becoming an indispensable tool to pursue precision medicine.
However, quickly translating newly developed magnetic resonance imaging (MRI) agents …

Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI

J Huang, PCM van Zijl, X Han, CM Dong… - Science …, 2020‏ - science.org
Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A
dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was …

Brain glucose activated mri contrast agent for early diagnosis of Alzheimer's disease

J Liu, C Chen, H Chen, C Huang, Q Ren… - Analytical …, 2022‏ - ACS Publications
Brain glucose is an important biomarker of Alzheimer's disease (AD) and has a high
specificity especially for early AD. Activatable magnetic resonance imaging (MRI) contrast …

d‐glucose weighted chemical exchange saturation transfer (glucoCEST)‐based dynamic glucose enhanced (DGE) MRI at 3T: early experience in healthy volunteers …

X Xu, AA Sehgal, NN Yadav, J Laterra… - Magnetic resonance …, 2020‏ - Wiley Online Library
Purpose Dynamic glucose enhanced (DGE) MRI has shown potential for imaging glucose
delivery and blood–brain barrier permeability at fields of 7T and higher. Here, we evaluated …

In vivo tracking of unlabelled mesenchymal stromal cells by mannose-weighted chemical exchange saturation transfer MRI

Y Yuan, C Wang, S Kuddannaya, J Zhang… - Nature biomedical …, 2022‏ - nature.com
The tracking of the in vivo biodistribution of transplanted human mesenchymal stromal cells
(hMSCs) relies on reporter genes or on the addition of exogenous imaging agents …

D-Glucose uptake and clearance in the tauopathy Alzheimer's disease mouse brain detected by on-resonance variable delay multiple pulse MRI

L Chen, Z Wei, KWY Chan, Y Li… - Journal of Cerebral …, 2021‏ - journals.sagepub.com
In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study
D-glucose uptake in a mouse model of Alzheimer's disease (AD) tauopathy and …

Relayed nuclear Overhauser enhancement imaging with magnetization transfer contrast suppression at 3 T

J Huang, X Han, L Chen, X Xu, J Xu… - Magnetic resonance in …, 2021‏ - Wiley Online Library
Purpose To develop a pulsed CEST magnetization‐transfer method for rapidly acquiring
relayed nuclear Overhauser enhancement (rNOE)–weighted images with magnetic transfer …

Sensitivity schemes for dynamic glucose‐enhanced magnetic resonance imaging to detect glucose uptake and clearance in mouse brain at 3 T

J Huang, JHC Lai, X Han, Z Chen, P **ao… - NMR in …, 2022‏ - Wiley Online Library
We investigated three dynamic glucose‐enhanced (DGE) MRI methods for sensitively
monitoring glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid …

Imaging self-healing hydrogels and chemotherapeutics using CEST MRI at 3 T

X Han, JHC Lai, J Huang, SW Park, Y Liu… - ACS Applied Bio …, 2021‏ - ACS Publications
Imaging hydrogel-based local drug delivery to the brain after tumor resection has
implications for refining treatments, especially for brain tumors with poor prognosis and high …