Acute bacterial meningitis

EC Wall, JM Chan, E Gil… - Current opinion in …, 2021 - journals.lww.com
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Streptococcus pneumoniae meningitis and the CNS barriers

E Gil, E Wall, M Noursadeghi, JS Brown - Frontiers in Cellular and …, 2023 - frontiersin.org
Streptococcus pneumoniae (SPN) is a globally significant cause of meningitis, the
pathophysiology of which involves damage to the brain by both bacterial virulence factors …

A comprehensive safety assessment of a novel starter Weissella confusa M1 combining with whole-genome sequencing

M Tian, H Wang, Y Li, J Wang, D Ren, K Lin - Food Research International, 2025 - Elsevier
At present, the range of starter cultures utilized in soybean fermented products is rather
limited. In our prior research, it was discovered that Weissella confusa holds potential as a …

Expert international trauma clinicians' views on the definition, composition and delivery of reintegration interventions for complex PTSD

M Condon, MAP Bloomfield, H Nicholls… - European Journal of …, 2023 - Taylor & Francis
Background: Research has previously distinguished between complex post-traumatic stress
disorder (CPTSD) and PTSD, with the former including a range of disturbances in self …

Targeted transcriptomic screen of pneumococcal genes expressed during murine and human infection

A Basset, E Wall, E Mitsi, C Deshusses… - Infection and …, 2022 - journals.asm.org
The advent of pneumococcal conjugate vaccines led to the near disappearance of most of
the included serotypes in high-income settings but also the rise of nonvaccine-type …

Addition of daptomycin for the treatment of pneumococcal meningitis: protocol for the AddaMAP study

P Chavanet, I Fournel, A Bourredjem, L Piroth, M Blot… - BMJ open, 2023 - bmjopen.bmj.com
Background The leading cause of acute bacterial meningitis in adults is Streptococcus
pneumoniae. This infection is associated with high rates of mortality and morbidity related …

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

EC Wall, JA Guerra-Assunção, M Yang, R Koning… - bioRxiv, 2024 - biorxiv.org
To better understand Streptococcus pneumoniae pathogenesis we performed RNA
sequencing on cerebrospinal fluid (CSF) from meningitis patients to identify bacterial genes …

The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality

JA Guerra-Assunção, P Chakravarty, G Pollara… - bioRxiv, 2024 - biorxiv.org
Background Pneumococcal meningitis (PM) has persistently poor clinical outcomes,
especially in sub-Saharan Africa. To better characterise the inflammatory response and …

Host-Pathogen Interaction in the Central Nervous System

T Barichello, F Iovino - Frontiers in Cellular and Infection Microbiology, 2021 - frontiersin.org
have provided a comprehensive study of how targeted transcriptomic analysis using mouse
models of chronic T. gondii infection can reveal differences in the host and parasite gene …

[BOOK][B] Study of the Feasibility and Diagnostic Accuracy of Proteomics and Next Generation Sequencing (NGS) for the Investigation of Neurosurgical Cerebrospinal …

L Van Tonder - 2022 - search.proquest.com
Neurosurgical cerebrospinal fluid (CSF) infections continue to affect a small portion of
patients despite clinical and technological advances in the field.. An infected neurosurgical …