From whole-slide image to biomarker prediction: end-to-end weakly supervised deep learning in computational pathology

OSM El Nahhas, M van Treeck, G Wölflein, M Unger… - Nature …, 2025 - nature.com
Hematoxylin-and eosin-stained whole-slide images (WSIs) are the foundation of diagnosis
of cancer. In recent years, development of deep learning-based methods in computational …

Characterising reproducibility debt in scientific software: A systematic literature review

Z Hassan, C Treude, M Norrish, G Williams… - Journal of Systems and …, 2024 - Elsevier
Context: In scientific software, the inability to reproduce results is often due to technical
issues and challenges in recreating the full computational workflow from the original …

Open and reusable deep learning for pathology with WSInfer and QuPath

JR Kaczmarzyk, A O'Callaghan, F Inglis, S Gat… - NPJ Precision …, 2024 - nature.com
Digital pathology has seen a proliferation of deep learning models in recent years, but many
models are not readily reusable. To address this challenge, we developed WSInfer: an open …

ConvNext Mitosis Identification—You Only Look Once (CNMI-YOLO): Domain Adaptive and Robust Mitosis Identification in Digital Pathology

Y Topuz, S Yıldız, S Varlı - Laboratory Investigation, 2024 - Elsevier
In digital pathology, accurate mitosis detection in histopathological images is critical for
cancer diagnosis and prognosis. However, this remains challenging due to the inherent …

[HTML][HTML] Weakly Supervised Multiple Instance Learning Model With Generalization Ability for Clinical Adenocarcinoma Screening on Serous Cavity Effusion Pathology

Y Zhang, X Zhu, L Zhong, J Wu, J Chen, H Yang… - Modern Pathology, 2025 - Elsevier
Accurate and rapid screening of adenocarcinoma cells in serous cavity effusion is vital in
diagnosing the stage of metastatic tumors and providing prompt medical treatment …

[HTML][HTML] Synergies and Challenges in the Preclinical and Clinical Implementation of Pathology Artificial Intelligence Applications

HA Qureshi, R Chetty, J Kuklyte, K Ratcliff… - Mayo Clinic …, 2023 - Elsevier
Recent introduction of digitalization in pathology has disrupted the field greatly with the
potential to change the area immensely. Digital pathology has created the potential of …

The Quest for the Application of Artificial Intelligence to Whole Slide Imaging: Unique Prospective from New Advanced Tools

G Faa, M Castagnola, L Didaci, F Coghe, M Scartozzi… - Algorithms, 2024 - mdpi.com
The introduction of machine learning in digital pathology has deeply impacted the field,
especially with the advent of whole slide image (WSI) analysis. In this review, we tried to …

An AI based, open access screening tool for early diagnosis of Burkitt lymphoma

N Nambiar, V Rajesh, A Nair, S Nambiar, R Nair… - Frontiers in …, 2024 - frontiersin.org
Burkitt Lymphoma (BL) is a highly treatable cancer. However, delayed diagnosis of BL
contributes to high mortality in BL endemic regions of Africa. Lack of enough pathologists in …

[HTML][HTML] HcGAN: Harmonic conditional generative adversarial network for efficiently generating high-quality IHC images from H&E

S Wu, S Xu - Heliyon, 2024 - cell.com
Generating high quality histopathology images like immunohistochemistry (IHC) stained
images is essential for precise diagnosis and the advancement of computer-aided …

Reproducibility and explainability in digital pathology: The need to make black-box artificial intelligence systems more transparent

G Faa, M Fraschini, L Barberini - Journal of Public Health …, 2024 - journals.sagepub.com
Artificial intelligence (AI), and more specifically Machine Learning (ML) and Deep learning
(DL), has permeated the digital pathology field in recent years, with many algorithms …