Sleep disturbances after general anesthesia: current perspectives

M Luo, B Song, J Zhu - Frontiers in neurology, 2020‏ - frontiersin.org
The purpose of this article is to review (1) sleep mechanism under general anesthesia,
harmful effects of postoperative sleep disturbances;(2) risk factors associated with …

Prophylactic use of exogenous melatonin and melatonin receptor agonists to improve sleep and delirium in the intensive care units: a systematic review and meta …

Q Zhang, F Gao, S Zhang, W Sun, Z Li - Sleep and Breathing, 2019‏ - Springer
To investigate the efficacy of exogenous administration of melatonin and melatonin receptor
agonists for the improvement of delirium, sleep, and other clinical outcomes of subjects in …

Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial

B Wibrow, FE Martinez, E Myers, A Chapman… - Intensive care …, 2022‏ - Springer
Purpose Delirium is common in the critically ill, highly distressing to patients and families
and associated with increased morbidity and mortality. Results of studies on preventative …

Melatonin for preoperative and postoperative anxiety in adults

BK Madsen, D Zetner, AM Møller… - Cochrane Database of …, 2020‏ - cochranelibrary.com
Background Anxiety in relation to surgery is a well‐known problem. Melatonin offers an
alternative treatment to benzodiazepines for ameliorating this condition in the preoperative …

Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta‐analysis

Y Han, J Wu, Z Qin, W Fu, B Zhao, X Li… - Journal of Pineal …, 2020‏ - Wiley Online Library
It remains unclear whether melatonin and its analogues prevent postoperative delirium
(POD). Therefore, we conducted a systematic review and meta‐analysis to evaluate the …

Trials focusing on prevention and treatment of delirium after cardiac surgery: a systematic review of randomized evidence

M Pieri, A De Simone, S Rose, P De Domenico… - Journal of cardiothoracic …, 2020‏ - Elsevier
Background Delirium after cardiac surgery is associated with adverse outcomes, including
prolonged hospital stay, prolonged intensive care unit stay, and increased mortality …

Promoting sleep and circadian health may prevent postoperative delirium: a systematic review and meta-analysis of randomized clinical trials

Y Lu, YW Li, L Wang, R Lydic, HA Baghdoyan… - Sleep medicine …, 2019‏ - Elsevier
This systematic review with meta-analysis and trial sequential analysis of randomized
clinical trials aimed to clarify the efficacy of sleep and circadian interventions on preventing …

The 50% and 95% effective dose of remimazolam tosilate for anaesthesia induction in sleep disorders patients undergoing laparoscopic cholecystectomy: an up-and …

Y **ao, Y Cao, J Pu, C Guo, Y Yi, Y Deng, Y Hu - BMC anesthesiology, 2024‏ - Springer
Purpose Previous reports argue that preoperative sleep conditions of patients can influence
the dosage of general anaesthesia drugs. Therefore, we aimed to investigate the dose-effect …

The Healthy Heart‐Mind trial: randomized controlled trial of melatonin for prevention of delirium

AH Ford, L Flicker, R Kelly, H Patel… - Journal of the …, 2020‏ - Wiley Online Library
OBJECTIVES Delirium is a serious medical condition with increased incidence in at‐risk
surgical populations. We sought to determine if melatonin use reduces the incidence of …

Melatonin and its analogs for prevention of post-cardiac surgery delirium: a systematic review and meta-analysis

Y Han, Y Tian, J Wu, X Zhu, W Wang… - Frontiers in …, 2022‏ - frontiersin.org
Background The effectiveness of melatonin and its analogs in preventing postoperative
delirium (POD) following cardiac surgery is controversial. The purpose of this systematic …