RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …

Many diseases are caused by insufficient expression of mutated genes and would benefit
from increased expression of the corresponding protein. However, in drug development, it …

Clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editors
are powerful tools in biology and hold great promise for the treatment of human diseases …

RNA is a central and universal mediator of genetic information underlying the diversity of cell
types and cell states, which together shape tissue organization and organismal function …

RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …

Summary Nonsense mutations, accounting for> 20% of disease-associated mutations, lead
to premature translation termination. Replacing uridine with pseudouridine in stop codons …

Recruiting the endogenous editing enzyme adenosine deaminase acting on RNA (ADAR)
with tailored guide RNAs for adenosine-to-inosine (A-to-I) RNA base editing is promising for …

With the advancement of sequencing technologies and bioinformatics, over than 170
different RNA modifications have been identified. However, only a few of these modifications …

Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and
phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of …

Rapid advancements have taken place in gene therapy technology. However, effective
methods for treating aging-or age-related chronic diseases, which are often closely related …