Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

The NOD-like receptor (NLR) family of proteins is a group of pattern recognition receptors
(PRRs) known to mediate the initial innate immune response to cellular injury and stress …

Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Recent studies have offered a glimpse into the sophisticated mechanisms by which
inflammasomes respond to danger and promote secretion of interleukin (IL)-1β and IL-18 …

The NLRP1 inflammasome is a multiprotein complex that is a potent activator of
inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial …

Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce
pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are …

Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …

Highlights•NLRP1 is a sensor of diverse pathogen-encoded activities.•'Functional
degradation'provides a mechanism for NLRP1 activation.•New insights into NLRP1 have …