Treatment resistant depression: a multi-scale, systems biology approach
An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …
Even with an eventual recovery, many patients require a trial and error approach, as there …
Ketamine: mechanisms and relevance to treatment of depression
JW Kim, K Suzuki, ET Kavalali… - Annual review of …, 2024 - annualreviews.org
Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-
based antidepressant drugs are a primary line of treatment for this mental disorder, although …
based antidepressant drugs are a primary line of treatment for this mental disorder, although …
Neurobiology of resilience: interface between mind and body
Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …
[HTML][HTML] Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2
A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …
Novel drug developmental strategies for treatment‐resistant depression
Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …
therapies are ineffective in many patients, novel strategies are needed to overcome …
Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice
Ketamine treatment decreases depressive symptoms within hours, but the mechanisms
mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity …
mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity …
Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression
YY van der Zee, LMT Eijssen, P Mews… - Molecular …, 2022 - nature.com
Major depressive disorder (MDD) is the leading cause of disability worldwide. There is an
urgent need for objective biomarkers to diagnose this highly heterogeneous syndrome …
urgent need for objective biomarkers to diagnose this highly heterogeneous syndrome …
Fighting females: neural and behavioral consequences of social defeat stress in female mice
Background Despite the twofold higher prevalence of major depressive and posttraumatic
stress disorders in women compared with men, most clinical and preclinical studies have …
stress disorders in women compared with men, most clinical and preclinical studies have …
Ketamine and serotonergic psychedelics: common mechanisms underlying the effects of rapid-acting antidepressants
Background The glutamatergic modulator ketamine has created a blueprint for studying
novel pharmaceuticals in the field. Recent studies suggest that “classic” serotonergic …
novel pharmaceuticals in the field. Recent studies suggest that “classic” serotonergic …
Vicarious social defeat stress induces depression-related outcomes in female mice
Background Stress is a prevailing risk factor for mood-related illnesses, wherein women
represent the majority of those affected by major depression. Despite the growing literature …
represent the majority of those affected by major depression. Despite the growing literature …