Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …

Radiotherapy has long been the mainstay of treatment for patients with head and neck
cancer and has traditionally involved a stage-dependent strategy whereby all patients with …

Background Prostate cancer might have high radiation-fraction sensitivity that would give a
therapeutic advantage to hypofractionated treatment. We present a pre-planned analysis of …

Background Radioresistance, a poorly understood phenomenon, results in the failure of
radiotherapy and subsequent local recurrence, threatening a large proportion of patients …

Objective Evidence shows that gene mutation is a significant proportion of genetic factors
associated with prostate cancer. The DNA damage response (DDR) is a signal cascade …

The advent of affordable and rapid next-generation DNA sequencing technology, along with
the US Supreme Court ruling invalidating gene patents, has led to a deluge of germline and …

Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-
analysis of two genome-wide association studies of leiomyoma in European women (16,595 …

Background Germline ATM mutations are suggested to contribute to predisposition to
prostate cancer (PrCa). Previous studies have had inadequate power to estimate variant …

While many efforts have been made to pave the way toward human space colonization, little
consideration has been given to the methods of protecting spacefarers against harsh cosmic …

Peptide receptor radionuclide therapy (PRRT) is a type of radiotherapy that targets peptide
receptors and is typically used for neuroendocrine tumours (NETs). Some of the key …