Insights on animal models to investigate inhalation therapy: relevance for biotherapeutics
Acute and chronic respiratory diseases account for major causes of illness and deaths
worldwide. Recent developments of biotherapeutics opened a new era in the treatment and …
worldwide. Recent developments of biotherapeutics opened a new era in the treatment and …
Effects of polystyrene nanoplastic gestational exposure on mice
X Wang, Z Zhao, X Wang, W Hu, X Chu, M Qian… - Chemosphere, 2023 - Elsevier
Airborne plastic particles have received increasing attention due to their ubiquity in the
atmosphere and potential human health risks. Previous studies have demonstrated that …
atmosphere and potential human health risks. Previous studies have demonstrated that …
In-vivo lung fibrosis staging in a bleomycin-mouse model: a new micro-CT guided densitometric approach
L Mecozzi, M Mambrini, F Ruscitti, E Ferrini… - Scientific reports, 2020 - nature.com
Although increasing used in the preclinical testing of new anti-fibrotic drugs, a thorough
validation of micro-computed tomography (CT) in pulmonary fibrosis models has not been …
validation of micro-computed tomography (CT) in pulmonary fibrosis models has not been …
Oscillometry of the respiratory system: a translational opportunity not to be missed
LKA Lundblad, A Robichaud - American Journal of …, 2021 - journals.physiology.org
Airway oscillometry has become the de facto standard for quality assessment of lung
physiology in laboratory animals and has demonstrated its usefulness in understanding …
physiology in laboratory animals and has demonstrated its usefulness in understanding …
Quantification of lung fibrosis in IPF-like mouse model and pharmacological response to treatment by micro-computed tomography
F Ruscitti, F Ravanetti, V Bertani, L Ragionieri… - Frontiers in …, 2020 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive degenerative lung disease
leading to respiratory failure and death. Although anti-fibrotic drugs are now available for …
leading to respiratory failure and death. Although anti-fibrotic drugs are now available for …
Distinct roles for type I and type III interferons in virulent human metapneumovirus pathogenesis
Y Zhang, J Xu, M Miranda-Katz, J Sojati… - Plos …, 2024 - journals.plos.org
Human metapneumovirus (HMPV) is an important cause of acute lower respiratory infection
in children and adults worldwide. There are four genetic subgroups of HMPV and both …
in children and adults worldwide. There are four genetic subgroups of HMPV and both …
Administration of bleomycin via the oropharyngeal aspiration route leads to sustained lung fibrosis in mice and rats as quantified by UTE-MRI and histology
C Egger, C Cannet, C Gérard, E Jarman, G Jarai… - PloS one, 2013 - journals.plos.org
Pulmonary fibrosis can be experimentally induced in small rodents by bleomycin. The
antibiotic is usually administered via the intratracheal or intranasal routes. In the present …
antibiotic is usually administered via the intratracheal or intranasal routes. In the present …
A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection
V Zhang, S Jenkitkasemwong, Q Liu, T Ganz… - Blood …, 2023 - ashpublications.org
Abstract ZIP8 (SLC39A8) is a transmembrane divalent metal ion importer that is most highly
expressed in the lung and is inducible by inflammatory stimuli. In addition to zinc and …
expressed in the lung and is inducible by inflammatory stimuli. In addition to zinc and …
Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
Idiopathic pulmonary fibrosis (IPF) is a deadly disease with a poor prognosis and few
treatment options. Pathological remodeling of the extracellular matrix (ECM) is a key factor …
treatment options. Pathological remodeling of the extracellular matrix (ECM) is a key factor …
Blockade of the NLRP3/caspase-1 axis ameliorates airway neutrophilic inflammation in a toluene diisocyanate-induced murine asthma model
S Chen, L Yao, P Huang, Q He, H Guan… - Toxicological …, 2019 - academic.oup.com
Multiple studies have addressed the vital role of Nod-like receptor protein 3
(NLRP3)/caspase-1/IL-1β signaling in asthma. Yet, the role of NLRP3/caspase-1 in toluene …
(NLRP3)/caspase-1/IL-1β signaling in asthma. Yet, the role of NLRP3/caspase-1 in toluene …