An update on extra-oral bitter taste receptors

K Tuzim, A Korolczuk - Journal of translational medicine, 2021‏ - Springer
Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

β2 Agonists

CK Billington, RB Penn, IP Hall - … and Therapeutics of Asthma and COPD, 2017‏ - Springer
History suggests β agonists, the cognate ligand of the β 2 adrenoceptor, have been used as
bronchodilators for around 5,000 years, and β agonists remain today the frontline treatment …

Pharmacology and therapeutics of bronchodilators

M Cazzola, CP Page, L Calzetta, MG Matera - Pharmacological reviews, 2012‏ - Elsevier
Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

Gene–environment interactions in human diseases

DJ Hunter - Nature reviews genetics, 2005‏ - nature.com
Studies of gene–environment interactions aim to describe how genetic and environmental
factors jointly influence the risk of develo** a human disease. Gene–environment …

Clinical application of pharmacogenetics

BB Spear, M Heath-Chiozzi, J Huff - Trends in molecular medicine, 2001‏ - cell.com
Pharmacogenetics encompasses the involvement of genes in an individual's response to
drugs. As such, the field covers a vast area including basic drug discovery research, the …

Randomized, Placebo-controlled Clinical Trial of an Aerosolized β2-Agonist for Treatment of Acute Lung Injury

National Heart, Lung, and Blood Institute … - American journal of …, 2011‏ - atsjournals.org
Rationale: β2-Adrenergic receptor agonists accelerate resolution of pulmonary edema in
experimental and clinical studies. Objectives: This clinical trial was designed to test the …

Molecular mechanisms of β2-adrenergic receptor function, response, and regulation

M Johnson - Journal of Allergy and Clinical Immunology, 2006‏ - Elsevier
The human β2-adrenoceptor is a member of the 7-transmembrane family of receptors,
encoded by a gene on chromosome 5, and widely distributed in the respiratory tract …

Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

CM Drysdale, DW McGraw, CB Stack… - Proceedings of the …, 2000‏ - pnas.org
The human β2-adrenergic receptor gene has multiple single-nucleotide polymorphisms
(SNPs), but the relevance of chromosomally phased SNPs (haplotypes) is not known. The …

Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial

E Israel, VM Chinchilli, JG Ford, HA Boushey… - The Lancet, 2004‏ - thelancet.com
Background The issue of whether regular use of an inhaled β 2-adrenergic agonist worsens
airflow and clinical outcomes in asthma is controversial. Retrospective studies have …

Signaling and regulation of G protein-coupled receptors in airway smooth muscle

CK Billington, RB Penn - Respiratory research, 2003‏ - Springer
Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth
muscle (ASM) functions including contraction, growth, and" synthetic" functions that …