Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited condition caused by
germline mutations of the TP53 tumor suppressor gene encoding p53, a transcription factor …

Somatic mutations in the TP53 gene are one of the most frequent alterations in human
cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which …

A large amount of data is available on the functional impact of missense mutations in TP53
and on mutation patterns in many different cancers. New data on mutant p53 protein …

Li–Fraumeni syndrome (LFS) is a complex hereditary cancer predisposition disorder
associated with early-onset cancers in diverse tissues of origin. Germline TP53 mutations …

The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in
TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of …

Through a comprehensive review and in silico analysis of reported data on STAT‐linked
diseases, we analysed the communication pathways and interactome of the seven STATs in …

Background More than 1000 reports have been published in the past two decades on
associations between variants in candidate genes and risk of breast cancer. Results have …

The tumor suppressor gene TP53, encoding p53, is expressed as several transcripts. The
fully spliced p53 (FSp53) transcript encodes the canonical p53 protein. The alternatively …

The p53 tumor suppressor gene continues to be distinguished as the most frequently
mutated gene in human cancer; this gene can be found mutated in up to 50% of human …

Li–Fraumeni syndrome (LFS) is a hereditary tumor that exhibits autosomal dominant
inheritance. LFS develops in individuals with a pathogenic germline variant of the cancer …