Chimeric antigen receptor (CAR) T cell therapy has garnered significant excitement due to
its success for hematological malignancies in clinical studies leading to the US Food and …

The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

Basement membranes are delicate, nanoscale and pliable sheets of extracellular matrices
that often act as linings or partitions in organisms. Previously considered as passive …

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …

The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …