From purines to purinergic signalling: molecular functions and human diseases
Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy
H Wu, Y Gong, P Ji, Y **e, YZ Jiang, G Liu - Journal of Hematology & …, 2022 - Springer
Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …
A new view into the regulation of purine metabolism: the purinosome
Other than serving as building blocks for DNA and RNA, purine metabolites provide a cell
with the necessary energy and cofactors to promote cell survival and proliferation. A …
with the necessary energy and cofactors to promote cell survival and proliferation. A …
Potential mechanisms connecting purine metabolism and cancer therapy
J Yin, W Ren, X Huang, J Deng, T Li, Y Yin - Frontiers in immunology, 2018 - frontiersin.org
Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of
nucleotides in cell proliferation, thus impaired purine metabolism is associated with the …
nucleotides in cell proliferation, thus impaired purine metabolism is associated with the …
The role of dynamic enzyme assemblies and substrate channelling in metabolic regulation
Transient physical association between enzymes appears to be a cardinal feature of
metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is …
metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is …
Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
Metabolons, multiprotein complexes consisting of sequential enzymes of a metabolic
pathway, are proposed to be biosynthetic “hotspots” within the cell. However, experimental …
pathway, are proposed to be biosynthetic “hotspots” within the cell. However, experimental …
The role of liquid–liquid phase separation in regulating enzyme activity
Liquid–liquid phase separation (LLPS) is now recognized as a common mechanism
underlying regulation of enzyme activity in cells. Insights from studies in cells are …
underlying regulation of enzyme activity in cells. Insights from studies in cells are …
Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
Phase separation of substrates and effectors is proposed to enhance biological reaction
rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching …
rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching …
Human de novo purine biosynthesis
The focus of this review is the human de novo purine biosynthetic pathway. The pathway
enzymes are enumerated, as well as the reactions they catalyze and their physical …
enzymes are enumerated, as well as the reactions they catalyze and their physical …
Spatial colocalization and functional link of purinosomes with mitochondria
Purine biosynthetic enzymes organize into dynamic cellular bodies called purinosomes.
Little is known about the spatiotemporal control of these structures. Using super-resolution …
Little is known about the spatiotemporal control of these structures. Using super-resolution …