The PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla,
has become a premiere model for the study of neuronal differentiation. When treated in …

The location of stem cells within the adult CNS makes them impractical for surgical removal
and autologous transplantation. Their limited availability and histocompatibility issues further …

Differentiation and neuritogenesis of mouse neuroblastoma Neuro2a cells are induced by
exogenous ganglioside but are not induced by nerve growth factor because its receptor is …

Gangliosides are being used therapeutically to treat a variety of nervous system disorders
including peripheral neuropathies and stroke. Gangliosides (over 70 molecular species) are …

The present study examined whether GABA treatments would affect the growth and
development of embryonic chick cortical and retinal neurons in culture. Incubation of these …

The expression of a single glycosyltransferase, GD3 synthase, caused cholinergic
differentiation with neurite sprouting. The cells that expressed GD3 were established from …

Early speculation on ganglioside function was fashioned in the belief that these substances
are localized primarily in the neuron. Current awareness of their widespread distribution has …

We have reported previously that genipin, a natural iridoid compound, induces
neuritogenesis through a nitric oxide (NO)–cyclic GMP (cGMP)–cGMP-dependent protein …

A procedure is described for assay of GM1 and other gangliotetraose-type gangliosides at
the picomole level. The gangliosides are adsorbed onto polystyrene microwells and treated …

Gangliosides are sialic acid-containing glycolipids present in high concentrations on the cell
surface of central nervous system cells where they may play a role in the process of signal …