Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …

Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

Bones are constantly remodeled throughout life to maintain robust structure and function.
Dysfunctional remodeling can result in pathological conditions such as osteoporosis (bone …

The acquisition and maintenance of bone mass and strength are influenced by
environmental factors, including physical activity and nutrition. Among micronutrients …

More than 300 million years ago, vertebrates emerged from the vast oceans to conquer
gravity and the dry land. With this transition, new adaptations occurred that included …

Adynamic bone disease (ABD) is a well-recognized clinical entity in the complex chronic
kidney disease (CKD)–mineral and bone disorder. Although the combination of low intact …

Our understanding of the regulation of phosphate balance has benefited tremendously from
the molecular identification and characterization of genetic defects leading to a number of …

During chronic kidney disease (CKD), alterations in bone and mineral metabolism include
increased production of the hormone fibroblast growth factor 23 (FGF23) that may contribute …

To date, attempts to regenerate a complete tooth, including the critical periodontal tissues
associated with the tooth root, have not been successful. Controversy still exists regarding …

The mechanisms by which inorganic phosphate (Pi) homeostasis controls bone biology are
poorly understood. Here we used Dmp1 null mice, a hypophosphatemic …