The colony-stimulating factors (CSFs) are a group of cytokines central to the hematopoiesis
of blood cells, the modulation of their functional responses, as well as the maintenance of …

The mononuclear phagocyte system (MPS) was defined as a family of cells comprising bone
marrow progenitors, blood monocytes, and tissue macrophages. In this review, we briefly …

The c-fms gene encodes the receptor for macrophage colony-stimulating factor (CSF-1). The
gene is expressed selectively in the macrophage and trophoblast cell lineages. Previous …

Establishing gene regulatory networks during differentiation or reprogramming requires
master or pioneer transcription factors (TFs) such as PU. 1, a prototype master TF of …

The F4/80 antigen, encoded by the Adgre1 locus, has been widely-used as a monocyte-
macrophage marker in mice, but its value as a macrophage marker in other species is …

The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine
leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli …

Ets is a family of transcription factors present in species ranging from sponges to human. All
family members contain an approximately 85 amino acid DNA binding domain, designated …

Mouse hematopoietic tissues contain abundant tissue-resident macrophages that support
immunity, hematopoiesis, and bone homeostasis. A systematic strategy to characterize …

Hematopoiesis is coordinated by a complex regulatory network of transcription factors and
among them PU. 1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the …

The proliferation, differentiation, and survival of cells of the mononuclear phagocyte system
(MPS; progenitors, monocytes, macrophages, and classical dendritic cells) are controlled by …