Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …

Synucleinopathies are characterized by the accumulation of α-synuclein (α-Syn) aggregates
in the brain. Positron emission tomography (PET) imaging of synucleinopathies requires …

Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …

This review article provides an overview of the different species that α‐synuclein aggregates
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …

To elucidate the relevance of gut dysbiosis in Parkinson's disease (PD) in disease
progression, we made random forest models to predict the progression of PD in two years by …

Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

In Parkinson's disease, intracellular α-synuclein inclusions form in neurons. We suggest that
prion-like behavior of α-synuclein is a key component in Parkinson's disease pathogenesis …

Parkinson's disease (PD) is a heterogenous disease with a varying age of onset, symptoms,
and rate of progression. This heterogeneity requires the use of a variety of animal models to …