Single-cell transcriptomics for the assessment of cardiac disease
AMA Miranda, V Janbandhu, H Maatz… - Nature Reviews …, 2023 - nature.com
Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice
The most common form of genetic heart disease is hypertrophic cardiomyopathy (HCM),
which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart …
which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart …
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance
Following injury, cells in regenerative tissues have the ability to regrow. The mechanisms
whereby regenerating cells adapt to injury-induced stress conditions and activate the …
whereby regenerating cells adapt to injury-induced stress conditions and activate the …
Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity
The accumulation of somatic DNA mutations over time is a hallmark of aging in many
dividing and nondividing cells but has not been studied in postmitotic human …
dividing and nondividing cells but has not been studied in postmitotic human …
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
M Grosch, L Schraft, A Chan, L Küchenhoff… - Nature …, 2023 - nature.com
Dilated cardiomyopathy is the second most common cause for heart failure with no cure
except a high-risk heart transplantation. Approximately 30% of patients harbor heritable …
except a high-risk heart transplantation. Approximately 30% of patients harbor heritable …
Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds
SK Swift, AL Purdy, ME Kolell, KG Andresen… - …, 2023 - journals.biologists.com
Somatic polyploidization, an adaptation by which cells increase their DNA content to support
growth, is observed in many cell types, including cardiomyocytes. Although polyploidization …
growth, is observed in many cell types, including cardiomyocytes. Although polyploidization …
Tbx5 maintains atrial identity in postnatal cardiomyocytes by regulating an atrial-specific enhancer network
Understanding how the atrial and ventricular heart chambers maintain distinct identities is a
prerequisite for treating chamber-specific diseases. In this study, we selectively knocked out …
prerequisite for treating chamber-specific diseases. In this study, we selectively knocked out …
Cardiac myoediting attenuates cardiac abnormalities in human and mouse models of Duchenne muscular dystrophy
Rationale: Absence of dystrophin in Duchenne muscular dystrophy (DMD) results in the
degeneration of skeletal and cardiac muscles. Owing to advances in respiratory …
degeneration of skeletal and cardiac muscles. Owing to advances in respiratory …
Single-nucleus RNA sequencing identifies cell-type–specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices
K Schmidt, M Fuchs, N Weber, C Werlein… - European Heart …, 2024 - academic.oup.com
* Corresponding author. Tel:+ 49 511 532 5272, Fax:+ 49 511 532 5274, Email: Thum.
Thomas@ mh-hannover. de† The first two authors contributed equally to the study and …
Thomas@ mh-hannover. de† The first two authors contributed equally to the study and …
Tbx5 maintains atrial identity by regulating an atrial enhancer network
Understanding how the atrial and ventricular chambers of the heart maintain their distinct
identity is a prerequisite for treating chamber-specific diseases. Here, we selectively …
identity is a prerequisite for treating chamber-specific diseases. Here, we selectively …