Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue
of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP …

In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …

Glucose metabolism is known to orchestrate oncogenesis. Whether glucose serves as a
signaling molecule directly regulating oncoprotein activity for tumorigenesis remains elusive …

Translational regulation plays a critical role during the oocyte-to-embryo transition (OET)
and zygotic genome activation (ZGA). Here, we integrated ultra-low-input ribosome profiling …

Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Long noncoding RNAs (lncRNAs) have gained widespread attention in recent years as a
potentially new and crucial layer of biological regulation. lncRNAs of all kinds have been …

Despite growing appreciation of the importance of long noncoding RNAs (lncRNAs) in
normal physiology and disease, our knowledge of cancer-related lncRNAs remains limited …

The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional
elements in the human genome sequence. The pilot phase of the Project is focused on a …

To derive a global perspective on the transcription of microRNAs (miRNAs) in mammals, we
annotated the genomic position and context of this class of noncoding RNAs (ncRNAs) in …