An expanded lexicon for the ubiquitin code
Our understanding of the ubiquitin code has greatly evolved from conventional E1, E2 and
E3 enzymes that modify Lys residues on specific substrates with a single type of ubiquitin …
E3 enzymes that modify Lys residues on specific substrates with a single type of ubiquitin …
[HTML][HTML] Targeting the ubiquitin–proteasome system and recent advances in Cancer Therapy
Ubiquitination is a reversible post-translational modification based on the chemical addition
of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination …
of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination …
Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms
The intracellular bacterial pathogen Legionella pneumophila modulates host cell functions
by secreting multiple effectors with diverse biochemical activities. In particular, effectors of …
by secreting multiple effectors with diverse biochemical activities. In particular, effectors of …
A new dawn beyond lysine ubiquitination
DR Squair, S Virdee - Nature Chemical Biology, 2022 - nature.com
The ubiquitin system has become synonymous with the modification of lysine residues.
However, the substrate scope and diversity of the conjugation machinery have been …
However, the substrate scope and diversity of the conjugation machinery have been …
ER remodeling via ER-phagy
The endoplasmic reticulum (ER) is a hotspot for many essential cellular functions. The ER
membrane is highly dynamic, which affects many cellular processes that take place within …
membrane is highly dynamic, which affects many cellular processes that take place within …
Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain
ADP-ribosylation is a reversible post-translational modification involved in various cellular
activities. Removal of ADP-ribosylation requires (ADP-ribosyl) hydrolases, with …
activities. Removal of ADP-ribosylation requires (ADP-ribosyl) hydrolases, with …
A lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins
Acute lysosomal membrane damage reduces the cellular population of functional
lysosomes. However, these damaged lysosomes have a remarkable recovery potential …
lysosomes. However, these damaged lysosomes have a remarkable recovery potential …
The ubiquitin codes in cellular stress responses
Ubiquitination/ubiquitylation, one of the most fundamental post-translational modifications,
regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown …
regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown …
The emerging roles of non-canonical ubiquitination in proteostasis and beyond
Ubiquitin regulates various cellular functions by posttranslationally modifying substrates with
diverse ubiquitin codes. Recent discoveries of new ubiquitin chain topologies, types of …
diverse ubiquitin codes. Recent discoveries of new ubiquitin chain topologies, types of …
Non-lysine ubiquitylation: Doing things differently
The post-translational modification of proteins with ubiquitin plays a central role in nearly all
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …
aspects of eukaryotic biology. Historically, studies have focused on the conjugation of …