Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

Immunological mechanisms and therapeutic targets of fatty liver diseases

H Wang, W Mehal, LE Nagy, Y Rotman - Cellular & Molecular …, 2021 - nature.com
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

Current options and future directions for NAFLD and NASH treatment

C Zhang, M Yang - International Journal of Molecular Sciences, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, with a broad spectrum ranging from simple steatosis to advanced stage of …

Vitamin E: How much is enough, too much and why!

MG Traber, B Head - Free Radical Biology and Medicine, 2021 - Elsevier
Abstract α-Tocopherol (α-T) is a required dietary nutrient for humans and thus is a vitamin.
This narrative review focuses on vitamin E structures, functions, biological determinants and …

mTOR: A potential new target in nonalcoholic fatty liver disease

J Feng, S Qiu, S Zhou, Y Tan, Y Bai, H Cao… - International journal of …, 2022 - mdpi.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) continues to rise, yet
effective treatments are lacking due to the complex pathogenesis of this disease. Although …

Understanding NAFLD: from case identification to interventions, outcomes, and future perspectives

D Clayton-Chubb, W Kemp, A Majeed, JS Lubel… - Nutrients, 2023 - mdpi.com
While non-alcoholic fatty liver disease (NAFLD) is a prevalent and frequent cause of liver-
related morbidity and mortality, it is also strongly associated with cardiovascular disease …

A molecular insight into the role of antioxidants in nonalcoholic fatty liver diseases

D Ezhilarasan, T Lakshmi - Oxidative Medicine and Cellular …, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) defines fat accumulation in the liver, and it is
commonly associated with metabolic syndromes like diabetes and obesity. Progressive …

Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease

Y Fu, Y Zhou, L Shen, X Li, H Zhang, Y Cui… - Frontiers in …, 2022 - frontiersin.org
The global incidence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 25%.
With the global increase in obesity and its associated metabolic syndromes, NAFLD has …

[HTML][HTML] The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

AB Behrooz, M Cordani, A Fiore, M Donadelli… - Seminars in Cancer …, 2024 - Elsevier
Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …

Preventive and therapeutic effects of natural products and herbal extracts on nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Y Cao, X Fang, M Sun, Y Zhang, M Shan… - Phytotherapy …, 2023 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a common condition that is prevalent in patients
who consume little or no alcohol, and is characterized by excessive fat accumulation in the …