Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that
regulates the cardiovascular system as a vasodepressor. Dysfunction of B2R is also closely …

Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted
neuropathological disorders. AD is characterized by intracellular accumulation of …

Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many through
engagement with more than 40G protein–coupled receptors. Searching for receptors to …

Designer receptors exclusively activated by designer drugs (DREADDs) represent a
powerful chemogenetic technology for the remote control of neuronal activity and cellular …

Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of
physiologies. A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain …

Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and
attractive targets for various diseases. aGPCRs are also known to be capable of self …

Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-
coupled receptors, is aberrantly overexpressed in several malignant tumors, including those …

Abstract Neurokinin 3 receptor (NK3R) is a tachykinin receptor essential for the
hypothalamic-pituitary-gonadal axis. The endogenous peptide agonist neurokinin B (NKB) …

Peptide hormones and neuropeptides are complex signaling molecules that predominately
function through G protein-coupled receptors (GPCRs). Two unanswered questions …

Hydroxycarboxylic acid receptors (HCAR1, HCAR2, and HCAR3) transduce Gi/o signaling
upon biding to molecules such as lactic acid, butyric acid and 3-hydroxyoctanoic acid, which …