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Detection technologies for RNA modifications
Y Zhang, L Lu, X Li - Experimental & molecular medicine, 2022 - nature.com
To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
[HTML][HTML] Epitranscriptome: review of top 25 most-studied RNA modifications
VA Arzumanian, GV Dolgalev, IY Kurbatov… - International Journal of …, 2022 - mdpi.com
The alphabet of building blocks for RNA molecules is much larger than the standard four
nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of …
nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of …
Semi-quantitative detection of pseudouridine modifications and type I/II hypermodifications in human mRNAs using direct long-read sequencing
Here, we develop and apply a semi-quantitative method for the high-confidence
identification of pseudouridylated sites on mammalian mRNAs via direct long-read …
identification of pseudouridylated sites on mammalian mRNAs via direct long-read …
RMDisease V2. 0: an updated database of genetic variants that affect RNA modifications with disease and trait implication
Recent advances in epitranscriptomics have unveiled functional associations between RNA
modifications (RMs) and multiple human diseases, but distinguishing the functional or …
modifications (RMs) and multiple human diseases, but distinguishing the functional or …
Quantification and map** of RNA modifications
J ** reveals a diverse dihydrouridine landscape including mRNA
Dihydrouridine is a modified nucleotide universally present in tRNAs, but the complete
dihydrouridine landscape is unknown in any organism. We introduce dihydrouridine …
dihydrouridine landscape is unknown in any organism. We introduce dihydrouridine …
Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders
HM Knight, MD Öz… - Neural Regeneration …, 2024 - journals.lww.com
The study of modified RNA known as epitranscriptomics has become increasingly relevant
in our understanding of disease-modifying mechanisms. Methylation of N6 adenosine (m 6 …
in our understanding of disease-modifying mechanisms. Methylation of N6 adenosine (m 6 …
All the sites we cannot see: Sources and mitigation of false negatives in RNA modification studies
S Oberdoeffer, WV Gilbert - Nature Reviews Molecular Cell Biology, 2024 - nature.com
RNA modifications are essential for human health—too much or too little of them leads to
serious illnesses ranging from neurodevelopmental disorders to cancer. Technical …
serious illnesses ranging from neurodevelopmental disorders to cancer. Technical …
Functional redundancy in tRNA dihydrouridylation
C Sudol, LM Kilz, V Marchand, Q Thullier… - Nucleic Acids …, 2024 - academic.oup.com
Dihydrouridine (D) is a common modified base found predominantly in transfer RNA (tRNA).
Despite its prevalence, the mechanisms underlying dihydrouridine biosynthesis, particularly …
Despite its prevalence, the mechanisms underlying dihydrouridine biosynthesis, particularly …