How to enter a bacterium: bacterial porins and the permeation of antibiotics
Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …
century, infectious diseases have remained a leading cause of death. More specifically …
Targeting the outer membrane of gram-negative foodborne pathogens for food safety: compositions, functions, and disruption strategies
M Liu, JH Cheng, H Zhao, C Yu… - Critical Reviews in Food …, 2024 - Taylor & Francis
Foodborne pathogens are a major threat to both food safety and public health. The current
trend toward fresh and less processed foods and the misuse of antibiotics in food production …
trend toward fresh and less processed foods and the misuse of antibiotics in food production …
Interaction of Tryptophan- and Arginine-Rich Antimicrobial Peptide with E. coli Outer Membrane—A Molecular Simulation Approach
A short antimicrobial peptide (AMP), rich in tryptophan and arginine (P6—HRWWRWWRR-
NH2), was used in molecular dynamics (MD) simulations to investigate the interaction …
NH2), was used in molecular dynamics (MD) simulations to investigate the interaction …
Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane
Gram-negative porins are the main entry for small hydrophilic molecules. We studied
translocation of structurally related cephalosporins, ceftazidime (CAZ), cefotaxime (CTX) and …
translocation of structurally related cephalosporins, ceftazidime (CAZ), cefotaxime (CTX) and …
Dual‐Color Real‐Time Chemosensing of a Compartmentalized Reaction Network Involving Enzyme‐Induced Membrane Permeation of Peptides
The design of synthetic systems with interrelated reaction sequences that model incipient
biological complexity is limited by physicochemical tools that allow the direct monitoring of …
biological complexity is limited by physicochemical tools that allow the direct monitoring of …
Selective Translocation of Cyclic Sugars through Dynamic Bacterial Transporter
The selective translocation of molecules through membrane pores is an integral process in
cells. We present a bacterial sugar transporter, CymA of unusual structural conformation due …
cells. We present a bacterial sugar transporter, CymA of unusual structural conformation due …
Molecular and supramolecular engineering on lipopeptide-based hole-punching nanotoxins to trigger multimodal death of drug-resistant tumors: Apoptosis, necrosis …
X Zhang, Y Li, Y Yang, K Deng, R Liu, R Hou… - Chemical Engineering …, 2023 - Elsevier
Discovering bioactive and efficient new agents for broad-spectrum multidrug resistance
reversal is a worldwide challenge in the biomedical field. Herein, bioactive nanomaterials …
reversal is a worldwide challenge in the biomedical field. Herein, bioactive nanomaterials …
Proton‐Gradient‐Driven Sensitivity Enhancement of Liposome‐Encapsulated Supramolecular Chemosensors
An overarching challenge in the development of supramolecular sensor systems is to
enhance their sensitivity, which commonly involves the synthesis of refined receptors with …
enhance their sensitivity, which commonly involves the synthesis of refined receptors with …
What have molecular simulations contributed to understanding of Gram-negative bacterial cell envelopes?
Bacterial cell envelopes are compositionally complex and crowded and while highly
dynamic in some areas, their molecular motion is very limited, to the point of being almost …
dynamic in some areas, their molecular motion is very limited, to the point of being almost …
Atomistic simulation of molecules interacting with biological nanopores: from current understanding to future directions
Biological nanopores have been at the focus of numerous studies due to their role in many
biological processes as well as their (prospective) technological applications. Among many …
biological processes as well as their (prospective) technological applications. Among many …