Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Aging and lung disease

SJ Cho, HW Stout-Delgado - Annual review of physiology, 2020 - annualreviews.org
People worldwide are living longer, and it is estimated that by 2050, the proportion of the
world's population over 60 years of age will nearly double. Natural lung aging is associated …

Respiratory epithelial cells orchestrate pulmonary innate immunity

JA Whitsett, T Alenghat - Nature immunology, 2015 - nature.com
The epithelial surfaces of the lungs are in direct contact with the environment and are
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

[HTML][HTML] Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis

O Cañadas, B Olmeda, A Alonso… - International journal of …, 2020 - mdpi.com
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and
secreted into the airspaces, where it coats and protects the large respiratory air–liquid …

Pulmonary surfactant pathophysiology: current models and open questions

J Perez-Gil, TE Weaver - Physiology, 2010 - journals.physiology.org
Pulmonary surfactant is an essential lipid-protein complex that stabilizes the respiratory units
(alveoli) involved in gas exchange. Quantitative or qualitative derangements in surfactant …

Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins

R Guagliardo, J Perez-Gil, S De Smedt… - Journal of Controlled …, 2018 - Elsevier
Pulmonary surfactant (PS) has been extensively studied because of its primary role in
mammalian breathing. The deposition of this surface-active material at the alveolar air-water …

Pulmonary surfactant metabolism in the alveolar airspace: Biogenesis, extracellular conversions, recycling

B Olmeda, M Martínez-Calle, J Pérez-Gil - Annals of Anatomy …, 2017 - Elsevier
Pulmonary surfactant is a lipid–protein complex that lines and stabilizes the respiratory
interface in the alveoli, allowing for gas exchange during the breathing cycle. At the same …

Synthetic surfactants with SP‐B and SP‐C analogues to enable worldwide treatment of neonatal respiratory distress syndrome and other lung diseases

J Johansson, T Curstedt - Journal of internal medicine, 2019 - Wiley Online Library
Abstract Treatment of neonatal respiratory distress syndrome (RDS) using animal‐derived
lung surfactant preparations has reduced the mortality of handling premature infants with …

Host defense and the airway epithelium: frontline responses that protect against bacterial invasion and pneumonia

NA Eisele, DM Anderson - Journal of pathogens, 2011 - Wiley Online Library
Airway epithelial cells are the first line of defense against invading microbes, and they
protect themselves through the production of carbohydrate and protein matrices …