The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …

Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …

Biallelic inactivation of the tumour suppressor gene Von Hippel–Lindau (VHL) occurs in the
vast majority of clear cell renal cell carcinoma (ccRCC) instances, disrupting cellular oxygen …

Several cancer core regulatory circuitries (CRCs) depend on the sustained generation of
DNA accessibility by SWI/SNF chromatin remodelers. However, the window when SWI/SNF …

Dilated cardiomyopathy (DCM) is a highly prevalent and genetically heterogeneous
condition that results in decreased contractility and impaired cardiac function. The FK506 …

PBRM1 is a subunit of the PBAF chromatin remodeling complex, which is mutated in 40–
50% of clear cell renal cell carcinoma patients. It is thought to largely function as a chromatin …

Alternative pre-mRNA splicing (AS) is a biological process that results in proteomic diversity.
However, implications of AS alterations in cancer remain poorly understood. Herein, we …

Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …

Bromodomains are acetyl-lysine binding modules that are found in different classes of
chromatin-interacting proteins. Among these are large chromatin remodeling complexes …

Here we show that striated muscle preferentially expressed protein kinase α (Spegα)
maintains cardiac function in hearts with Spegβ deficiency. Speg is required for stability of …