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Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates
The increasing prevalence of poorly soluble drugs in development provides notable risk of
new products demonstrating low and erratic bioavailabilty with consequences for safety and …
new products demonstrating low and erratic bioavailabilty with consequences for safety and …
Compression physics in the formulation development of tablets
The advantages of high-precision dosing, manufacturing efficiency, and patient compliance
make tablets the most popular dosage forms. Compaction, an essential manufacturing step …
make tablets the most popular dosage forms. Compaction, an essential manufacturing step …
Phase transition enthalpy measurements of organic and organometallic compounds and ionic liquids. Sublimation, vaporization, and fusion enthalpies from 1880 to …
The second part of this compendium concludes with a collection of phase change enthalpies
of organic molecules inclusive of C 11–C 192 reported over the period 1880–2015. Also …
of organic molecules inclusive of C 11–C 192 reported over the period 1880–2015. Also …
Drug carrier systems for solubility enhancement of BCS class II drugs: a critical review
Poor aqueous solubility impedes a drug's bioavailability and challenges its pharmaceutical
development. Pharmaceutical development of drugs with poor water solubility requires the …
development. Pharmaceutical development of drugs with poor water solubility requires the …
Formation of phenytoin nanoparticles using rapid expansion of supercritical solution with solid cosolvent (RESS-SC) process
Nanoparticles are of significant importance in drug delivery. Rapid expansion of supercritical
solution (RESS) process can produce pure and high-quality drug particles. However, due to …
solution (RESS) process can produce pure and high-quality drug particles. However, due to …
Process intensification for pharmaceutical crystallization
Process intensification (PI) provides great opportunities to drastically improve the
performance of chemical processes within many branches of chemical industry including the …
performance of chemical processes within many branches of chemical industry including the …
Multistage crystallization of plate-like crystals: A modeling and experimental study on adipic acid
Particles exhibiting a plate-like shape, encountered during crystallization, present
challenges in downstream processing. Consequently, it is crucial to manipulate the size and …
challenges in downstream processing. Consequently, it is crucial to manipulate the size and …
Impact of crystal habit on biopharmaceutical performance of celecoxib
Poor biopharmaceutical performance of Biopharmaceutical Classification System (BCS)
class II drug molecules is a major hurdle in the design and development of pharmaceutical …
class II drug molecules is a major hurdle in the design and development of pharmaceutical …
Nano-extrusion: A promising tool for continuous manufacturing of solid nano-formulations
R Baumgartner, A Eitzlmayr, N Matsko… - International journal of …, 2014 - Elsevier
Since more than 40% of today's drugs have low stability, poor solubility and/or limited ability
to cross certain biological barriers, new platform technologies are required to address these …
to cross certain biological barriers, new platform technologies are required to address these …