Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …

Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …

The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …

Triple-negative breast cancer (TNBC) is an aggressive disease characterized by remarkable
intratumor heterogeneity (ITH), which poses therapeutic challenges. However, the clinical …

Abstract Transposable elements (TEs) comprise~ 50% of our genome, but knowledge of
how TEs affect genome evolution remains incomplete. Leveraging ENCODE4 data, we …

Endogenous retroviruses (ERVs) are frequently reactivated in mammalian placenta. It has
been proposed that ERVs contribute to sha** the gene regulatory network of mammalian …

Transposable elements (TEs) are abundant in the genomes of various eukaryote organisms.
Increasing evidence suggests that TEs can play crucial regulatory roles—usually by creating …

The present perspective article proposes an etiopathological model for multiple sclerosis
pathogenesis and progression associated with the activation of human endogenous …

Transposable elements (TEs) are indispensable for human development, with critical
functions in pluripotency and embryogenesis. TE sequences also contribute to human …

Summary Long interspersed element-1 (LINE-1 or L1) comprises 17% of the human
genome, continuously generates genetic variations, and causes disease in certain cases …