Th17 cells in human disease
LA Tesmer, SK Lundy, S Sarkar… - Immunological reviews, 2008 - Wiley Online Library
Our understanding of the role of T cells in human disease is undergoing revision as a result
of the discovery of T‐helper 17 (Th17) cells, a unique CD4+ T‐cell subset characterized by …
of the discovery of T‐helper 17 (Th17) cells, a unique CD4+ T‐cell subset characterized by …
[HTML][HTML] Engineering interferons and interleukins for cancer immunotherapy
Cytokines are a class of potent immunoregulatory proteins that are secreted in response to
various stimuli and act locally to regulate many aspects of human physiology and disease …
various stimuli and act locally to regulate many aspects of human physiology and disease …
Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor
L Cosmi, R De Palma, V Santarlasci, L Maggi… - The Journal of …, 2008 - rupress.org
We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T
helper cell (Th17) clones and that all IL-17–producing cells are contained in the CD161+ …
helper cell (Th17) clones and that all IL-17–producing cells are contained in the CD161+ …
Epigenetic control of T-helper-cell differentiation
CB Wilson, E Rowell, M Sekimata - Nature reviews immunology, 2009 - nature.com
Naive CD4+ T cells give rise to T-helper-cell subsets with functions that are tailored to their
respective roles in host defence. The specification of T-helper-cell subsets is controlled by …
respective roles in host defence. The specification of T-helper-cell subsets is controlled by …
The Effect of Periodontitis on Expression of Interleukin‐21: A Systematic Review
Purpose. Inflammation and tissue breakdown are led by an array of inflammatory destructive
mediators associated with initiation and progression of inflammatory diseases like …
mediators associated with initiation and progression of inflammatory diseases like …
Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia
B Santner-Nanan, MJ Peek, R Khanam… - The Journal of …, 2009 - journals.aai.org
Preeclampsia is the leading cause of morbidity and mortality in pregnancy. Although the
etiology of preeclampsia is still unclear, it is believed to involve rejection of the fetus …
etiology of preeclampsia is still unclear, it is believed to involve rejection of the fetus …
Clinical significance and immunobiology of IL-21 in autoimmunity
D Long, Y Chen, H Wu, M Zhao, Q Lu - Journal of autoimmunity, 2019 - Elsevier
Abstract Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular
helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the …
helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the …
HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy
A Couture, A Garnier, F Docagne, O Boyer… - Frontiers in …, 2019 - frontiersin.org
CD4+ T cells differentiate into various T helper subsets characterized by distinct cytokine
secreting profiles that confer them effector functions adapted to a variety of infectious or …
secreting profiles that confer them effector functions adapted to a variety of infectious or …
The role of IL‐21 in regulating B‐cell function in health and disease
Interleukin‐21 (IL‐21) belongs to a family of cytokines that includes IL‐2, IL‐4, IL‐7, IL‐9,
and IL‐15, all of which bind to private (or shared) receptors as well as the common cytokine …
and IL‐15, all of which bind to private (or shared) receptors as well as the common cytokine …
Regulatory T and T helper 17 cells: Their roles in preeclampsia
Regulatory T (Treg) cells have been identified as key immune regulators and are important
to fetal survival within the maternal uterus. T helper 17 (Th17) cells have also emerged as a …
to fetal survival within the maternal uterus. T helper 17 (Th17) cells have also emerged as a …