Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

P Asgharian, AP Tazekand, K Hosseini… - Cancer cell …, 2022 - Springer
Over the past few years, the cancer-related disease has had a high mortality rate and
incidence worldwide, despite clinical advances in cancer treatment. The drugs used for …

Anticancer drug discovery based on natural products: From computational approaches to clinical studies

P Chunarkar-Patil, M Kaleem, R Mishra, S Ray… - Biomedicines, 2024 - mdpi.com
Globally, malignancies cause one out of six mortalities, which is a serious health problem.
Cancer therapy has always been challenging, apart from major advances in …

[HTML][HTML] Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications

S Ijaz, J Iqbal, BA Abbasi, Z Ullah, T Yaseen… - Biomedicine & …, 2023 - Elsevier
Cancer is still the leading cause of death worldwide, burdening the global medical system.
Rosmarinic acid (RA) is among the first secondary metabolites discovered and it is a …

Targeting apoptotic pathway of cancer cells with phytochemicals and plant-based nanomaterials

AK Wani, N Akhtar, TG Mir, R Singh, PK Jha, SK Mallik… - Biomolecules, 2023 - mdpi.com
Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via
the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly …

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

J Sharifi-Rad, V Seidel, M Izabela… - Cell Communication and …, 2023 - Springer
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism.
The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative …

Therapeutic role of alkaloids and alkaloid derivatives in cancer management

K Olofinsan, H Abrahamse, BP George - Molecules, 2023 - mdpi.com
Cancer is a neoplastic disease that remains a global challenge with a reported prevalence
that is increasing annually. Though existing drugs can be applied as single or combined …

Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery

Z Hui, H Wen, J Zhu, H Deng, X Jiang, XY Ye… - Bioorganic …, 2024 - Elsevier
Natural products represent a paramount source of novel drugs. Numerous plant-derived
natural products have demonstrated potent anti-tumor properties, thereby garnering …

Plant hormones and secondary metabolites under environmental stresses: Enlightening defense molecules

S Kumari, F Nazir, C Maheshwari, H Kaur… - Plant Physiology and …, 2024 - Elsevier
The climatic changes have great threats to sustainable agriculture and require efforts to
ensure global food and nutritional security. In this regard, the plant strategic responses …

[HTML][HTML] Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview

D Kitic, B Miladinovic, M Randjelovic, A Szopa… - Plants, 2022 - mdpi.com
Prunus armeniaca L.(Rosaceae)-syn. Amygdalus armeniaca (L.) Dumort., Armeniaca
armeniaca (L.) Huth, Armeniaca vulgaris Lam is commonly known as the apricot tree. The …

Drug development, Brazilian biodiversity and political choices: Where are we heading?

PMP Ferreira, DDR Arcanjo… - Journal of Toxicology and …, 2023 - Taylor & Francis
The aim of this review was to (i) acknowledge structural advantages of natural products
(NPs) for designing therapeutic drugs;(ii) emphasize how wildlife conservation is socially …