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TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Goods and bads of the endocannabinoid system as a therapeutic target: lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
A microbiome-dependent gut–brain pathway regulates motivation for exercise
Exercise exerts a wide range of beneficial effects for healthy physiology 1. However, the
mechanisms regulating an individual's motivation to engage in physical activity remain …
mechanisms regulating an individual's motivation to engage in physical activity remain …
[HTML][HTML] The endocannabinoid system: a potential target for the treatment of various diseases
H Lowe, N Toyang, B Steele, J Bryant… - International journal of …, 2021 - mdpi.com
The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …
balance in internal environment (temperature, mood, and immune system) and energy input …
Antioxidative and anti-inflammatory properties of cannabidiol
S Atalay, I Jarocka-Karpowicz, E Skrzydlewska - Antioxidants, 2019 - mdpi.com
Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …
The polypharmacological effects of cannabidiol
Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753).
This naturally occurring secondary metabolite does not induce intoxication or exhibit the …
This naturally occurring secondary metabolite does not induce intoxication or exhibit the …
Synthetic cannabinoids: a pharmacological and toxicological overview
R Roque-Bravo, RS Silva, RF Malheiro… - Annual review of …, 2023 - annualreviews.org
Synthetic cannabinoids (SCs) are a chemically diverse group of new psychoactive
substances (NPSs) that target the endocannabinoid system, triggering a plethora of actions …
substances (NPSs) that target the endocannabinoid system, triggering a plethora of actions …
The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
P Facheris, J Jeffery, E Del Duca… - Cellular & molecular …, 2023 - nature.com
Atopic dermatitis (AD) is the most common inflammatory skin disease, and it is considered a
complex and heterogeneous condition. Different phenotypes of AD, defined according to the …
complex and heterogeneous condition. Different phenotypes of AD, defined according to the …
Sebaceous immunobiology-skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations
This review presents several aspects of the innovative concept of sebaceous
immunobiology, which summarizes the numerous activities of the sebaceous gland …
immunobiology, which summarizes the numerous activities of the sebaceous gland …
The pharmacological case for cannabigerol
Medical cannabis and individual cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC)
and cannabidiol (CBD), are receiving growing attention in both the media and the scientific …
and cannabidiol (CBD), are receiving growing attention in both the media and the scientific …