Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …

Protein ubiquitination is of great cellular importance through its central role in processes
such as degradation, DNA repair, endocytosis and inflammation. Canonical ubiquitination …

Mammalian target of rapamycin (mTOR) senses changes in nutrient status and stimulates
the autophagic process to recycle amino acids. However, the impact of nutrient stress on …

Medical Biochemistry is supported by over forty years of teaching experience, providing
coverage of basic biochemical concepts, including the structure and physical and chemical …

Genetic, epidemiologic, and biochemical evidence suggests that predisposition to
Alzheimer's disease (AD) may arise from altered cholesterol metabolism, although the …

Various forms of programmed cell death (PCD) exhibit distinct characteristics depending on
their specific molecular mechanisms, and there are interactions among these different forms …

Lipids are essential molecules that play key roles in cell physiology by serving as structural
components, for storage of energy, and in signal transduction. Hence, efficient regulation …

Cancer immunotherapies using adoptive T cell transfer have achieved great success
(Rosenberg et al., 2008; Restifo et al., 2012). CD8+ T cells play a central role in antitumor …

Ubiquitin linkage to cysteine is an unconventional modification targeting protein for
degradation. However, the physiological regulation of cysteine ubiquitylation is still …

Cholesterol is an essential molecule in cellular membranes, but too much cholesterol can be
toxic. Therefore, mammalian cells have developed complex mechanisms to remove excess …