Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …

This article is one of ten reviews selected from the Annual Update in Intensive Care and
Emergency Medicine 2019. Other selected articles can be found online at https://www …

Background Mechanical ventilation (MV) is a core intensive care unit (ICU) therapy.
Significant inter-and intra-patient variability in lung mechanics and condition makes …

The pathophysiology of acute respiratory distress syndrome (ARDS) results in
heterogeneous lung collapse, edema-flooded airways and unstable alveoli. These …

Acute respiratory distress syndrome (ARDS) alters the dynamics of lung inflation during
mechanical ventilation. Repetitive alveolar collapse and expansion (RACE) predisposes the …

Acute respiratory distress syndrome (ARDS) is associated with a heterogeneous pattern of
injury throughout the lung parenchyma that alters regional alveolar opening and collapse …

Acute respiratory distress syndrome (ARDS) causes a heterogeneous lung injury and
remains a serious medical problem, with one of the only treatments being supportive care in …

In the pursuit of science, competitive ideas and debate are necessary means to attain
knowledge and expose our ignorance. To quote Murray Gell-Mann (1969 Nobel Prize …

Repeated applications of tidal energy inflict lung damage (VILI) when stress and strain
exceed the limits of tissue tolerance. Inflation work and energy are the products of pressure …

A hallmark of ARDS is progressive shrinking of the 'baby lung,'now referred to as the
ventilator-induced lung injury (VILI)'vortex.'Reducing the risk of the VILI vortex is the goal of …