Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under
glucose starvation; the nature of the latter cell death remains unknown. Here we show that …

Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT)
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …

Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …