Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …

One of the most promising areas in the therapeutics for metabolic diseases centers around
activation of the pathways of energy expenditure. Brown adipose tissue is a particularly …

Certain white adipose tissue (WAT) depots are readily able to convert to a “brown-like” state
with prolonged cold exposure or exposure to β-adrenergic compounds. This process is …

White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …

Although it is well established that physical activity increases mitochondrial content in
muscle, the molecular mechanisms underlying this process have only recently been …

The white adipose organ is composed of both subcutaneous and several intra-abdominal
depots. Excess abdominal adiposity is a major risk factor for metabolic disease in rodents …

Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …

Brown fat can increase energy expenditure and protect against obesity through a
specialized program of uncoupled respiration. Here we show by in vivo fate map** that …

A detailed understanding of the processes governing adipose tissue formation will be
instrumental in combating the obesity epidemic. Much progress has been made in the last …

Brown fat cells are specialized to dissipate energy and can counteract obesity; however, the
transcriptional basis of their determination is largely unknown. We show here that the zinc …