Since its recent discovery, the meningeal lymphatic system has reshaped our understanding
of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking …

The dura, arachnoid and pia mater, as the constituent layers of the meninges, along with
cerebrospinal fluid in the subarachnoid space and ventricles, are essential protectors of the …

Lymphatic transport maintains homeostatic health and is necessary for immune surveillance,
and yet lymphatic growth is often associated with solid tumour development and …

Old age is associated with a decline in cognitive function and an increase in
neurodegenerative disease risk. Brain ageing is complex and is accompanied by many …

Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …

The central nervous system (CNS) is endowed with its own resident innate immune cells, the
microglia. They constitute approximately 10% of the total cells within the CNS parenchyma …

Brain health is intimately connected to fluid flow dynamics that cleanse the brain of
potentially harmful waste material. This system is regulated by vascular dynamics, the …

Background Alzheimer's disease (AD) is pathologically characterized by the abnormal
accumulation of Aβ and tau proteins. There has long been a keen interest among …

The term “glymphatic” emerged roughly a decade ago, marking a pivotal point in
neuroscience research. The glymphatic system, a glial-dependent perivascular network …

The precise neurophysiological changes prompted by meningeal lymphatic dysfunction
remain unclear. Here, we showed that inducing meningeal lymphatic vessel ablation in adult …