The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

Aims The mechanisms underlying persistent atrial fibrillation (AF) in patients with atrial
fibrosis are poorly understood. The goal of this study was to use patient-derived atrial …

Since myocardial fibers drive the electric signal propagation throughout the myocardium,
accurately modeling their arrangement is essential for simulating heart electrophysiology …

Background: Pulmonary vein isolation (PVI) is an effective treatment strategy for patients
with atrial fibrillation (AF), but many experience AF recurrence and require repeat ablation …

Integrating spatial information about atrial physiology and anatomy in a single patient from
multimodal datasets, as well as generalizing these data across patients, requires a common …

Background Modeling the whole cardiac function involves the solution of several complex
multi-physics and multi-scale models that are highly computationally demanding, which call …

Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant
drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy …

This review article gives a comprehensive survey of the progress made in computational
modeling of the human atria during the last 10 years. Modeling the anatomy has emerged …

Introduction: The genesis of atrial fibrillation (AF) and success of AF ablation therapy have
been strongly linked with atrial fibrosis. Increasing evidence suggests that patient-specific …