ALS genetics, mechanisms, and therapeutics: where are we now?
The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …
as the number of genes associated with the disease risk and pathogenesis, and the cellular …
Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases
Apoptosis is crucial for the normal development of the nervous system, whereas neurons in
the adult CNS are relatively resistant to this form of cell death. However, under pathological …
the adult CNS are relatively resistant to this form of cell death. However, under pathological …
Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes
Amyotrophic lateral sclerosis (ALS) is a progressively fatal neurodegenerative disease
affecting motor neurons in the brain and spinal cord. In this study, we investigated gene …
affecting motor neurons in the brain and spinal cord. In this study, we investigated gene …
Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
KA Guttenplan, MK Weigel, DI Adler… - Nature …, 2020 - nature.com
Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative
diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We …
diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We …
Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice
Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated
from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors …
from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors …
Decoding ALS: from genes to mechanism
Amyotrophic lateral sclerosis (ALS) is a progressive and uniformly fatal neurodegenerative
disease. A plethora of genetic factors have been identified that drive the degeneration of …
disease. A plethora of genetic factors have been identified that drive the degeneration of …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex
Oligodendrocyte generation in the adult CNS provides a means to adapt the properties of
circuits to changes in life experience. However, little is known about the dynamics of …
circuits to changes in life experience. However, little is known about the dynamics of …
Oligodendrocyte lineage cells and depression
B Zhou, Z Zhu, BR Ransom, X Tong - Molecular psychiatry, 2021 - nature.com
Depression is a common mental illness, affecting more than 300 million people worldwide.
Decades of investigation have yielded symptomatic therapies for this disabling condition but …
Decades of investigation have yielded symptomatic therapies for this disabling condition but …
Astrocyte scar formation aids central nervous system axon regeneration
Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are
widely regarded as causal in this failure. Here, using three genetically targeted loss-of …
widely regarded as causal in this failure. Here, using three genetically targeted loss-of …